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*Figure includes clinical trial and estimated real-world injections as of 6/30/24.
Reference: 1. Data on file. Apellis Pharmaceuticals, Inc.
Note:
*Defined as patients with study-eye investigator-determined new-onset nAMD.
AMD=age-related macular degeneration; CNV=choroidal neovascularization; FA=fluorescein angiography; IOP=intraocular pressure; IVT=intravitreal; nAMD=neovascular age-related macular degeneration; VEGF=vascular endothelial growth factor.
*Total does not include 1 incident of endophthalmitis with negative vitreous culture results in the EOM group that appeared to be associated with an impurity in the drug product lots at the beginning of the study, which has been successfully removed by optimization of the manufacturing process.2
EOM=every other month.
*This group does not include the 10 patients from Phase 1b Study 103 who were included in the GALE safety set.2
EOM=every other month; nAMD=neovascular age-related macular degeneration.
*Total includes 1 incident of endophthalmitis with negative vitreous culture results in the EOM group that appeared to be associated with an impurity in the drug product lots at the beginning of the study, which has been successfully removed by optimization of the manufacturing process.2
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