OAKS and DERBY
In OAKS, 31% of patients in the monthly group, 21% of patients in the every other month and 25% of the patients assigned to sham discontinued treatment prior to Year 2. In DERBY, 29% of patients in the monthly group, 22% of patients in the every other month and 21% of the patients assigned to sham discontinued treatment prior to Year 2.4
The most frequent reasons for discontinuation from treatment were consent withdrawal (10%), death (4%), adverse events (4%), and COVID-19 impact (4%).1
Among all patients enrolled in OAKS and DERBY who received at least one injection of SYFOVRE or sham, 75% completed their respective study through Year 2 (n=940/1256).1
GALE
Through Years 1 and 2 of GALE, 18.4% of patients in the continued monthly group, 23.0% of patients in the continued EOM group, 24.0% of patients in the sham monthly to SYFOVRE monthly group, and 20.1% of patients in the sham EOM to SYFOVRE EOM group discontinued treatment.1
The most frequent reasons for discontinuation were consent withdrawl (9.2%), death (5.2%), and adverse events (3.2%).1